8-(Methyl sulfo nyl)-2,6-dihydroimidazo[1,2-c]pyrimidine-5- (3H)-ones — new heterocyclic derivatives of sulfones with antiviral activity

Title8-(Methyl sulfo nyl)-2,6-dihydroimidazo[1,2-c]pyrimidine-5- (3H)-ones — new heterocyclic derivatives of sulfones with antiviral activity
Publication TypeJournal Article
Year of Publication2019
AuthorsSolomyannyi, RM, Brovarets, VS, Shablykina, OV, Moskvina, VS, Khilya, VP
Abbreviated Key TitleDopov. Nac. akad. nauk Ukr.
DOI10.15407/dopovidi2019.05.075
Issue5
SectionChemistry
Pagination75-81
Date Published05/2019
LanguageUkrainian
Abstract

By the interaction of 3-(R-amino)-2-(methylsulfonyl)acrylonitrile and 1-isocyanate-2-chloroethane, new sulfonе analogues of cytosine, 8-(methylsulfonyl)-6-R-2,6-dihydroimidazo[1,2-c]pyrimidine-5(3H)-ones, are synthesized. The antiviral activity of 8-(methylsulfonyl)-6-benzyl-2,6-dihydroimidazo[1,2-c]pyrimidine-5(3H)-one has been proven.

Keywords2-c]pyrimidine- 5(3H)-one, 3-amino-2-(methylsulfonyl)acrylonitrile, 6-dihydroimidazo[1, 8-(methylsulfonyl)-2, antiviral activity, heterocyclylization
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