| Title | (Isocoumarin-3-yl)phenoxyacetic acids in the amino acid derivatives synthesis. Structure and activity |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Shilin, SV, Shablykina, OV, Ishchenko, VV, Khylia, VP |
| Abbreviated Key Title | Dopov. Nac. akad. nauk Ukr. |
| DOI | 10.15407/dopovidi2017.01.082 |
| Issue | 1 |
| Section | Chemistry |
| Pagination | 82-87 |
| Date Published | 1/2017 |
| Language | Ukrainian |
| Abstract | The relative reactivities of (isocoumarin-3-yl)- and (3,4-dihydroisocoumarin-3-yl)phenoxyacetic acids in the synthesis of amino acid derivatives, which includes the activated N-hydroxysuccinimide esters producing, are studied. It is found that, for the compounds with unsaturated isocoumarin cycle, the rate of activated ester formation is significantly reduced, when a substituent (regardless of size) in the ortho position to the oxyacetic acid fragment appears. While the slowing interaction of their saturated analogues with N-hydroxysuccinimide is not observed due to the presence of the ortho substituent. |
| Keywords | (3, (isocoumarin-3-yl)phenoxyacetic acids, 4-dihydroisocoumarin-3-yl)phenoxyacetic acids, activated ester method, amino acid derivatives, N-hydroxysuccinimide |
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